Abstract: OBJECTIVE To study the chemical constituents of ethyl acetate fraction from Patrinia scabra Bunge. METHODS Chemical constituents were isolated and purified by silica gel and Sephadex LH-20 column chromatography. Their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. RESULTS Eleven compounds were isolated and purified. Their structures were identified as 7α-O-methylmorroniside(1), 7β-O-methylmorroniside(2), 1-octanol(3), 2,3-nonyl olefin(4), lariciresinol (5), Jatamanin J(6), lariciresinol-4-O-β-D-glucopyrano-side(7), patriscabrol(8) Jatamanin A(9), Scabroside A(10), daturic acid 2, 3-dihydroxyopropyl(11). CONCLUSION Compounds 1-4 are isolated from this plant for the first time, the compound 3 and 4 were isolated from Patrinia Juss. for the first time.