Abstract: OBJECTIVE To explore the research situation of the evolution of the processing history, processing technology and pharmacological action of the Corni Fructus with wine. METHODS Consult and categorize the relevant research of processing historical materials of the Corni Fructus with wine and to sum up the evolution of the processing history, the records of the processing procedures, clinical efficacy and compound application of it, the variations of the chemical constituents, quality control and the pharmacological actions after being processed Corni Fructus s with wine were be summarized. RESULTS The processing method of Corni Fructus with wine was described in the Sui and Tang dynasty, and has been recorded in many provinces. But it had not been well completed studied on the quality control standards and pharmacological activities. CONCLUSION It is necessary to research on the chemical constituents and pharmacological activities of wine Corni Fructus deeply and it could provide a theoretical basis for revealing processing principle and scientific connotation.