Abstract: OBJECTIVE To observe the clinical curative effects and safety of Wuteng Chongji and methotrexate in the treatment of rheumatoid arthritis. METHODS The 102 cases of rheumatoid arthritis patients were randomly divided into treatment group(52 cases) and observation group(50 cases). Observation group oral methotrexate tablets, treatment group in the observation group on the basis of the oral Wuteng Chongji, and the course of treatment was 12 weeks observed before and after treatment in patients with symptoms, signs and laboratory indicators of change. RESULTS In the treatment group, the total effective rate was 96.00%. In the observation group, the total efficiency of 81.63%, there was significant difference between two groups(P<0.05). After treatment, in the two groups, the tender joint number, tenderness index, swelling index, swollen joint count, DAS28, CRP, time of morning stiffness, grip strength, HAQ score had significant difference(P<0.05 or P<0.01), the VAS score, ESR had no statistical difference(P>0.05). CONCLUSION Wuteng Chongji and methotrexate in the treatment of rheumatoid arthritis can significantly improve symptoms, signs and inflammatory index. They are better than single use of methotrexate tablets.