Abstract: OBJECTIVE To prepare bezafibrate nanostructured lipid carriers(BZF-NLC) and evaluate the quality. METHODS BZF-NLC was prepared by melt-emulsification method, and the optimal prescription was screened by orthogonal experiment. The morphology of BZF-NLC was observed by scanning electron microscope. Zeta potential, particle size and distribution were determined by granulometer. The entrapment efficiency was determined by Sephadex gel column chromatography. RESULTS BZF-NLC prepared under optimum conditions was approximately spherical with average particle size of (127.6±3.16) nm, PDI of 0.191±0.02, which were distributed evenly, and zeta potential of (-28.4±0.7)mV, encapsulation efficiency of (94.28±1.09)%, respectively. The profiles of BZF-NLC in vitro release had the features of sustainedrelease. CONCLUSION It shows that there are good physicochemical properties of BZF-NLC prepared by melt-emulsification method, and had a certain degree of sustained-release effect.