Abstract: OBJECTIVE To optimize the extraction technology of Shenhuang recipe. METHODS Comprehensive evaluation score by analytic hierarchy process as the 6 indexs, such as the free anthraquinones in Rhubarb, honokiol and tanshinone Ⅱ_A extraction rate, extract rate. The effects of ethanol concentration, drug-solvent ratio and extraction times on extraction were investigated by orthogonal test. The extraction technology was optimized and validation test was conducted. RESULTS The optimum extraction process was as follows, 6-fold 60% ethanol, 80℃ water bath heating reflux extracting 3 times, 1 h each time. The validation test showed that the average extraction rate of emodin, rhein, chrysophanol, honokiol and tanshinone Ⅱ_A were 70.48%, 57.36%, 83.87%, 49.18%, 83.87%, and the average extract rate was 37.27%. CONCLUSION The optimized extraction process is simple, stable and low cost, which can be used for the extraction of Shenhuang recipe, and it is helpful to promote the study of the compound preparation.