Abstract: OBJECTIVE To evaluate the interventional effect of pharmacy service on patients with mental disorder in community, in order to provide reference for promoting such pharmacy service for more patients in other communities. METHODS Ninety patients with severe mental disorder in community were selected and randomly assigned into treatment group and control group(n=45). Patients in control group were merely received regular medicine therapy, while the treatment group were received pharmacy service additionally. Evaluated the outcome employing Social Disability Screening Schedule (SDSS), Activity of Daily Living Scale (ADL) as well as the compliance and stability of patient to compare the interventional effect. RESULTS Before treatment, there were no significant difference between the patients in both groups in each scale assessment. After treatment, total scores as well as each column score of ADL and SDSS showed significant differences between the two groups(P<0.05). Within group, before and after treatment, there was no significant difference of ADL and SDSS assessments in control group, but each and total scores decreased significantly in treatment group(P<0.05). After treatment, patients in treatment group processed better compliance and were in more stable condition than their counterpart, with the differences showing statistical significance(P<0.05). CONCLUSION Effective pharmacy service on patients with severe mental disorder in community can significantly improve their medication compliance as well as their living and social ability.