Abstract: OBJECTIVE To evaluate the efficacy and safety of total glucosides of peony(TGP) combined with antihistamines in the treatment of chronic urticaria. METHODS CNKI, VIP, Wanfang, PubMed, EMbase and Cochrane library database were researched, and the randomized controlled trials of TGP combined antihistamines for treatment of chronic urticarial were collected. Data were extracted and evaluated by two reviewers independently with a designed extraction form. The RevMan 5.2 software was used to carry out meta analysis. RESULTS The 19 studies invoving 1 606 patients were included. The results of meta-analysis indicated that the treatment success rate of TGP combined with antihistamines was significantly higher than that of antihistamines(P<0.000 01). Subgroup-analysis showed that the TGP significantly increased the efficacy of mizolastine(P<0.000 01), cetirizine(P=0.000 4), and desloratadine(P<0.000 01), fexofenadine(P<0.000 1) and ebastine(P<0.002). The incidence of diarrhea in the treated group were also higher than that of the control group(P=0.009). CONCLUSION TGP combined antihistamines in the treatment of chronic urticaria is effective, but had more adverse events of diarrhea.