Abstract: OBJECTIVE To evaluate the impact of clinical pharmacist interventions on blood pressure control in patients with hypertension. METHODS PubMed, Embase, The Cochrane Library, CNKI, VIP and Wanfang Data databases were searched from inception to Sep 2015 for randomized controlled trials (RCTs) investigating the impact of pharmacist interventions on blood pressure control in patients with hypertension. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed the methodological quality of included studies. Meta-analysis was performed using RevMan 5.3 software. RESULTS A total of 8 RCTs involving 2 056 patients were included. Compared with usual care, clinical pharmacist interventions showed greater reduction in systolicMD=-5.15 mmHg, 95%CI(-6.54, -3.76), P<0.000 01 and diastolic blood pressureMD=-3.01 mmHg, 95%CI (-4.51, -1.51), P<0.000 1. Additionally, pharmacist interventions improved the control rate of blood pressureRR=1.45, 95%CI(1.32, 1.60), P<0.000 01. CONCLUSION Pharmacist interventions are useful for improving clinical management of hypertension. Cooperation between physician and clinical pharmacist can be a successful strategy for managing hypertension.