Abstract: OBJECTIVE To compare the anti-arrhythmic effects of crebanine(Cre) and Cre liposomes. METHODS Used the arrhythmia model of rats caused by barium chloride or aconitine, to compare antiarrhythmic effects of Cre and Cre liposomes. RESULTS To arrhythmia induced by barium chloride, both of the high or low dose group of Cre liposomes (5, 2.5 mg·kg^-1) could restore rats' sinus rhythm, and maintain rats' sinus rhythm to 20 min, the result was significantly higher than the saline group (P<0.01); Cre liposomes (5 mg·kg^-1) could significantly delay the time of VP, VT, VF death which caused by aconitine, compared with NS, the difference was of great significance(P<0.01); compared with the same dose of Cre solution, VF appear time of Cre liposomes was longer (P<0.01). CONCLUSION Crebanine liposomes have some therapeutic effects on arrhythmia induced by barium chloride, and it also have a preventive effect on arrhythmia induced by aconitine.