Abstract: Annexin A2 is a calciumion-induced phospholipid binding properties of proteins, belonging to members of the family of membrane proteins, and it is widely distributed in all kinds of eukaryotic cell membrane, cytoplasm and tissue fluid. It is mainly expressed in human endothelial cells, monocytes, macrophages, dendritic cells, trophoblast cells, epithelial cells and tumor cells. Annexin A2 has various functions, which is mainly involved in membrane transport and a series activity which is depends on the activity of calmodulin in the surface of cell membrane, such as cell spit role in membrane fusion, vesicle transportation, cell adhesion, cell proliferation, apoptosis, replication, signal conduction and ion channel formation, many diseases and in vivo regulation are related to Annexin A2. According to recent reports in the literatures, a summarize about the structure and function of Annexin A2 in diseases will be writed.