Abstract: OBJECTIVE To evaluate the glucocorticoid associated with anti-thyroid drugs and anti-thyroid drugs alone to treatment Graves' disease is whether effective and safety. METHODS All randomized controlled trials (RCTs) comparing glucocorticoid associated anti-thyroid drugs with anti-thyroid drugs alone for the management of Graves'disease were identified by manual and computer retrieval. To evaluate by the Cochrane quality evaluation standard, and statistical analysis using Revman5.3 system. RESULTS In 10 study, glucocorticoid associated with anti-thyroid drugs group can effectively reduce the FT3, FT4, T4 levels, there were significant difference(P<0.01). But the T3, TSH levels had no obvious difference. Glucocorticoid associated with anti-thyroid drugs group has a lower incidence of adverse reactions. CONCLUSION Glucocorticoid associated with anti-thyroid drugs to treat Graves' disease has a good curative effect on the improvement of the FT3, FT4, T4. And it security is higher.