| 引用本文: | 王瑞,王雨佳,李贵轲,余正勇,金凡茂,赵健铤,杨志斌.美廉净凝胶的抗炎、镇痛及抗瘙痒作用研究[J].中国现代应用药学,2021,38(2):143-147. |
| WANG Rui,WANG Yujia,LI Guike,YU Zhengyong,JIN Fanmao,ZHAO Jianting,YANG Zhibin.Study on Anti-inflammatory, Analgesic and Anti-pruritus Effects of Meilianjing Gel[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(2):143-147. |
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| 美廉净凝胶的抗炎、镇痛及抗瘙痒作用研究 |
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王瑞1, 王雨佳1, 李贵轲1, 余正勇1,2, 金凡茂1, 赵健铤1, 杨志斌1
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1.大理大学, 云南省昆虫生物医药研发重点实验室, 药用特种昆虫开发国家地方联合工程研究中心, 中国西南药用昆虫及蛛形类资源开发利用协同创新中心, 云南 大理 671000;2.文山学院, 云南 文山 663000
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| 摘要: |
| 目的 研究美廉净凝胶抗炎、镇痛及抗瘙痒的作用。方法 通过蛋清液致小鼠足肿胀试验，羧甲基纤维素钠（carboxymethylcellulose sodium，CMC-Na）致小鼠皮下气囊白细胞游走试验，棉球致小鼠肉芽肿试验考察美廉净凝胶的抗炎作用；通过醋酸致小鼠扭体反应试验考察美廉净凝胶的镇痛作用；通过右旋糖酐-40致小鼠瘙痒试验考察美廉净凝胶抑制瘙痒的作用。结果 美廉净凝胶各剂量组均可抑制蛋清液所致小鼠足趾肿胀；各剂量组均可降低小鼠致痒后30 min内的挠抓次数，但无统计学差异；高剂量组能显著抑制CMC-Na致炎后3 h的小鼠皮下气囊白细胞游走（P<0.05），高、中剂量组均能显著抑制CMC-Na致炎后6 h的小鼠皮下气囊白细胞游走（P<0.05）；高剂量组可明显促进棉球诱导小鼠肉芽组织增生（P<0.01），且能降低醋酸致小鼠扭体的次数（P<0.05）。结论 美廉净凝胶具有明显的抗炎、镇痛作用，且有一定的抗瘙痒效果。 |
| 关键词: 美廉净凝胶 抗炎 镇痛 抗瘙痒 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.02.003 |
| 分类号:R969.2 |
| 基金项目:国家自然科学基金项目（81660605，81860742，81860765）；云南省教育厅科学研究基金产业化培育项目（2016CYH15） |
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| Study on Anti-inflammatory, Analgesic and Anti-pruritus Effects of Meilianjing Gel |
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WANG Rui1, WANG Yujia1, LI Guike1, YU Zhengyong1,2, JIN Fanmao1, ZHAO Jianting1, YANG Zhibin1
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1.Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, National Local Joint Engineering Research Center for the Development of Medicinal Special Insects, Collaborative Innovtion Center for the Exploitation and Utilization of Medicinal Insects and Arachnids in Southwest China, Dali University, Dali 671000, China;2.Wenshan University, Wenshan 663000, China
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| Abstract: |
| OBJECTIVE To study anti-inflammatory, analgesic and anti-pruritus effect of Meilianjing gel. METHODS The anti-inflammatory effects of Meilianjing gel were investigated by the tests of using egg white solution to induce foot swelling in mice, carboxymethylcellulose sodium(CMC-Na) to induce leukocyte migration in subcutaneous balloon in mice, and cotton ball to induce granuloma in mice. The analgesic effect of Meilianjing gel was investigated by the test of acetic acid-induced writhing reaction in mice. The inhibition effect of Meilianjing gel on pruritus in mice induced by dextran-40 was investigated. RESULTS Each dose group of Meilianjing gel could inhibit the toe swelling of mice induced by egg white liquid. Each dose group could reduce the scratching frequency of mice within 30 min after itchiness, but there was no statistical difference. The high-dose group could significantly inhibit the leukocyte migration in the subcutaneous air sac of mice 3 h after the inflammation induced by CMC-Na(P<0.05), while the high-dose and medium-dose groups could significantly inhibit the leukocyte migration in the subcutaneous air sac of mice 6 h after the inflammation induced by CMC-Na(P<0.05). The high-dose group could significantly promote granulation tissue hyperplasia induced by cotton balls in mice(P<0.01), and the high-dose group could reduce the number of writhing induced by acetic acid in mice(P<0.05). CONCLUSION Meilianjing gel has obvious anti-inflammatory and analgesic effect, and has anti-pruritus effect. |
| Key words: Meilianjing gel anti-inflammatory analgesia anti-pruritus |
