细胞色素P450酶的表观遗传学调控及研究进展

张轶雯; 方罗; 郑小卫; 李清林; 童莹慧; 鲍美华; 黄萍<sup>*</sup>

引用本文:	张轶雯,方罗,郑小卫,李清林,童莹慧,鲍美华,黄萍.细胞色素P450酶的表观遗传学调控及研究进展[J].中国现代应用药学,2017,34(2):293-297.
	ZHANG Yiwen,FANG Luo,ZHENG Xiaowei,LI Qinglin,TONG Yinghui,BAO Meihua,HUANG Ping.Study Advance on Epigenetic Regulation of Cytochrome P450 Enzymes[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(2):293-297.

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细胞色素P450酶的表观遗传学调控及研究进展
张轶雯¹, 方罗¹, 郑小卫¹, 李清林¹, 童莹慧¹, 鲍美华², 黄萍¹
1.浙江省肿瘤医院药剂科, 杭州 310022;2.长沙医学院, 长沙 410219

摘要:

细胞色素P450（CYPs）家族是体内重要的药物代谢酶，其功能主要是代谢临床药物及外源性物质。长期以来，CYP450酶的个体间功能活性差异往往被认为是由基因多态性所导致。然而随着研究的日益深入，人们发现基因序列的改变并不能完全解释CYP450酶的个体间活性差异。表观遗传学作为研究DNA序列未发生变化而基因表达发生可遗传变异的学科，可作为重要研究手段进一步解释CYP450酶的个体差异。该学科主要研究内容包括DNA甲基化、组蛋白翻译后修饰和RNA编辑等。本文就各主要CYP450酶的表观遗传学调控研究进行综述并讨论其在药物代谢和临床应用中的意义。

关键词: 细胞色素P450酶表观遗传学调控代谢

DOI：10.13748/j.cnki.issn1007-7693.2017.02.031

分类号:R284.1；R917.101

基金项目:国家自然科学基金（81503165）；浙江省中医药科技计划项目（2015ZA038）

Study Advance on Epigenetic Regulation of Cytochrome P450 Enzymes

ZHANG Yiwen¹, FANG Luo¹, ZHENG Xiaowei¹, LI Qinglin¹, TONG Yinghui¹, BAO Meihua², HUANG Ping¹

1.Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou 310022, China;2.Changsha Medical University, Changsha 410219, China

Abstract:

The cytochromes P450 (CYPs) are a family of drug-metabolizing enzymes, which are responsible for the major part of metabolism of clinically important drugs and xenobiotic substances. The high interindividual variability in CYP450 expression and activity is used attributed to gene polymorphism, while it can not explain all the variability. Epigenetics is the study of cellular and physiological phenotypic trait variations that are due to external factors that switch genes on and off and affect how cells read genes. Unlike genetics based on changes to the DNA sequence (the genotype), the changes in gene expression or cellular phenotype, these changes include histone proteins post-translational modification, DNA methylation and miRNAs. In this review, we summary the epigenetic studies on human CYP450, illusion the regulation of epigenetic on expression of these drug-metabolizing enzymes, discuss its significance in drug metabolism and clinical applications clinical practice.

Key words: CYP450 epigenetics regulation metabolism