微乳凝胶经皮给药制剂的研究与应用进展

谢明华; 葛敏; 高建青<sup>*</sup>

引用本文:	谢明华,葛敏,高建青.微乳凝胶经皮给药制剂的研究与应用进展[J].中国现代应用药学,2015,32(6):764-768.
	XIE Minghua,GE Min,GAO Jianqing.Progress of Investigation and Application for Microemulsion-based Gels Transdermal Delivery System[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(6):764-768.

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微乳凝胶经皮给药制剂的研究与应用进展
谢明华¹, 葛敏¹, 高建青²
1.杭州市余杭区第一人民医院，杭州 311100;2.浙江大学药学院，杭州 310058

摘要:

目的介绍微乳凝胶经皮给药制剂的研究与应用进展。方法根据近年来国内外相关文献，对微乳凝胶作为经皮给药载体的处方筛选、制备、体外释药性能、质量检查、研究应用进展等方面进行介绍。结果微乳凝胶具有显著增强药物的经皮渗透能力、降低药物刺激性和延缓药物释放等作用，且更便于给药。结论微乳凝胶有望成为一种具有重要应用价值的经皮给药新剂型。

关键词: 微乳凝胶载体经皮给药

DOI：

分类号:

基金项目:杭州市余杭区科技计划课题(201209)；浙江省药学会医院药学专项科研基金项目(2012ZYY17)

Progress of Investigation and Application for Microemulsion-based Gels Transdermal Delivery System

XIE Minghua¹, GE Min¹, GAO Jianqing²

1.The First People’s Hospital of Yuhang District, Hangzhou 311100, China;2.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

Abstract:

OBJECTIVE To introduce the progress of investigation and application for microemulsion-based gels transdermal delivery system. METHODS Reviewed the domestic and international articles, to introduce the prescription screening, preparation, in vitro release, quality checks and the progress of investigation and application for microemulsion-based gels transdermal delivery system. RESULTS Microemulsion-based gels could increase penetration rate, reduce the irritation, extend the drug action time, and use easy. CONCLUSION It is suggested that microemulsion-based gels is a promising carrier for transdermal drug delivery system.

Key words: microemulsion gel carrier transdermal delivery system