豨莶草的小鼠急性毒性及抗小鼠急性痛风性关节炎作用

蒋芳萍; 傅旭春<sup>*</sup>; 白海波

引用本文:	蒋芳萍,傅旭春,白海波.豨莶草的小鼠急性毒性及抗小鼠急性痛风性关节炎作用[J].中国现代应用药学,2013,30(12):1289-1291.
	JIANG Fangping,FU Xuchun,BAI Haibo.Mice Acute Toxicity of Siegesbeckia and Its Effect on Mouse Acute Gouty Arthritis[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(12):1289-1291.

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豨莶草的小鼠急性毒性及抗小鼠急性痛风性关节炎作用
蒋芳萍^1,2, 傅旭春³, 白海波²
1.浙江大学药学院，杭州 310058;2.杭州华东医药集团生物工程研究院有限公司，杭州 310011;3.浙江大学城市学院药物研究所，杭州 310015

摘要:

目的研究豨莶草醇提物和水提物的小鼠急性毒性及抗小鼠急性痛风性关节炎作用。方法 Bliss法计算豨莶草醇提物和水提物的LD₅₀；以尿酸钠诱导建立小鼠急性痛风性关节炎模型，观察豨莶草醇提物和水提物的抗关节肿胀作用。结果以豨莶草生药计，豨莶草醇提物的LD50为267.00 g·kg^-1，豨莶草水提物的LD50为147.91 g·kg^-1；小鼠急性痛风性关节炎模型组、给药24 h后豨莶草醇提物组和豨莶草水提物组的关节肿胀度分别为(0.134 8±0.049 3)，(0.098 0±0.034 0)和(0.117 2±0.024 0)mL。结论豨莶草醇提物的急性毒性显著低于豨莶草水提物；豨莶草醇提物的抗尿酸钠诱导的小鼠急性痛风性关节肿胀作用优于豨莶草水提物。

关键词: 豨莶草醇提物半数致死量痛风性关节炎

DOI：

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基金项目:杭州市科技发展计划项目

Mice Acute Toxicity of Siegesbeckia and Its Effect on Mouse Acute Gouty Arthritis

JIANG Fangping^1,2, FU Xuchun³, BAI Haibo²

1.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China;2.Hangzhou Huadong Medicine Group Biotechnology R&D Institute Co.,Ltd., Hangzhou 310011, China;3.Institate of Materia Medica, Zhejiang University City College, Hangzhou 310015, China

Abstract:

OBJECTIVE To study the mouse acute toxicity of both ethanol extract and water extract from siegesbeckia and their effects on mouse acute gouty arthritis. METHODS Bliss method was used to calculate the LD₅₀ of siegesbeckia extracts, and the mouse acute gouty arthritis model induced by sodium uric acid was observed. RESULTS LD50 of ethanol extract and water extract from siegesbeckia were 267.00 g·kg^-1 and 147.91 g·kg^-1, respectively. The joint swelling degrees of acute gouty arthritis mouse 24 h after the modeling were (0.134 8±0.049 3), (0.098 0±0.034 0) and (0.117 2±0.024 0) mL for model group, ethanol extract group and water extract group, respectively. CONCLUSION The acute toxicity of ethanol extract from siegesbeckia is significantly lower than the water extract, and the effect of ethanol extract on mouse acute gout joint swelling induced by sodium uric acid is better than water extract.

Key words: siegesbeckia ethanol extract LD₅₀ gouty arthritis