| 引用本文: | 朱雅艳，华俊彦，田伟强，张颖异.HPLC考察硫酸头孢噻利在右旋糖酐注射液中的配伍稳定性[J].中国现代应用药学,2011,28(12):1132-1135. |
| ZHU Yayan, HUA Junyan, TIAN Weiqiang, ZHANG Yingyi.Compatible Stability of Cefoselis Sulfate for Injection in Dextran 40 Glucose Injection by HPLC[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(12):1132-1135. |
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| 摘要: |
| 目的 考察注射用硫酸头孢噻利在右旋糖酐40葡萄糖注射液中的配伍稳定性。方法 考察配伍液分别在4，25，37 ℃下，6 h内外观、pH值的变化，同时采用高效液相色谱法(HPLC)测定配伍液中硫酸头孢噻利的含量变化。结果 在4，25，37 ℃下配伍液6 h内外观、pH值、含量无明显变化。结论 硫酸头孢噻利与右旋糖酐40葡萄糖注射液在6 h内配伍稳定。 |
| 关键词: 高效液相色谱法 硫酸头孢噻利 配伍 稳定性 |
| DOI： |
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| 基金项目:浙江省医学会基金项目(2007ZYC57) |
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| Compatible Stability of Cefoselis Sulfate for Injection in Dextran 40 Glucose Injection by HPLC |
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ZHU Yayan, HUA Junyan, TIAN Weiqiang, ZHANG Yingyi1,2
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1.Pharmacy Department, Lishui Central Hospital , Lishui 323000, China;2.College of Pharmaceutical Science, Wenzhou Medical College, Wenzhou 325035, China
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| Abstract: |
| OBJECTIVE To study the compatible stability of cefoselis sulsate for injection in dextran 40 glucose injection. METHODS Investigated the transmutation of the compatible fluid in appearance, pH value in 6 h at 4, 25, 37 ℃, then determined the content of cefoselis sulsate in dextran 40 glucose injection by HPLC. RESULTS There were no obvious changes in appearance, pH value, and also no significant changes in the content of the compatible fluid in 6 h at 4, 25, 37 ℃. CONCLUSION The cefoselis sulsate for injection is stable in 6 hours after mixing with dextran 40 glucose injection. |
| Key words: HPLC cefoselis sulfate compatible stability |
