鼻腔给药在神经系统疾病治疗中的研究进展

杨丽; 侯曙光<sup>*</sup>; 周璇

引用本文:	杨丽,侯曙光,周璇.鼻腔给药在神经系统疾病治疗中的研究进展[J].中国现代应用药学,2023,40(20):2865-2871.
	YANG Li,HOU Shuguang,ZHOU Xuan.Research Progress of Intranasal Drug Delivery System for Treatment of Central Nervous System Diseases[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(20):2865-2871.

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鼻腔给药在神经系统疾病治疗中的研究进展
杨丽¹, 侯曙光², 周璇³
1.海南美康达药业有限公司, 成都 610093;2.成都中医药大学, 成都 611137;3.成都砥睿医药科技有限公司, 成都 610093

摘要:

鼻腔给药可以避开血脑屏障、胃肠道降解和肝脏首过效应，经过嗅神经通路直接到达脑部，因而被用于多种神经系统疾病的治疗。本文综述了鼻腔解剖、鼻腔给药治疗中枢神经系统疾病的转运通路、作用机制、临床应用、面临挑战和新技术等方面的研究进展。

关键词: 鼻腔给药中枢神经系统血脑屏障递送系统

DOI：10.13748/j.cnki.issn1007-7693.20232209

分类号:R969.3

基金项目:

Research Progress of Intranasal Drug Delivery System for Treatment of Central Nervous System Diseases

YANG Li¹, HOU Shuguang², ZHOU Xuan³

1.Hainan Meikangda Pharmaceutical Co., Ltd., Chengdu 610093, China;2.Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;3.Chengdu Dirui Pharmaceutical Technology Co., Ltd., Chengdu 610093, China

Abstract:

Intranasal drug administration can avoid the blood-brain barrier, gastrointestinal degradation and liver first-pass effect, and may directly deliver drugs to the brain through the olfactory nerve pathway, so it is being used for the treatment of various neurological diseases. This article reviewed the research progress of intranasal drug delivery in terms of nasal anatomy, transport pathways of intranasal drug delivery for central nervous system diseases, mechanisms of action, clinical application, challenges and novel technologies.

Key words: intranasal administration central nerve system blood brain barrier drug delivery system