Preparation and in Vitro and in Vivo Experiments of Mesoporous Silica Nanoparticles Solubilizing Fenofibrate Tablets

OBJECTIVE To explore the preparation and in vitro and in vivo experiments of mesoporous silica nanoparticles(HK) solubilizing fenofibrate(FNB) tablets. METHODS HK was used as a carrier for FNB to make the solid dispersion(FNB-HK) with the method of adsorption. The existing state of fenofibrate in FNB-HK was analyzed by differential scanning calorimetry, X-ray diffraction and Fourier transform infrared spectroscopy. The dissolution experiment in vitro was conducted to optimize the formulation. Rabbits were administrated with the self-made tablets made according to the optimized formulation and commercial tablets in a single oral dose. The concentration of the rabbits’ plasma were determined by HPLC. RESULTS The characterization of FNB-HK showed that HK inhibited the crystallization of fenofibrate. Through optimizing formulation, the dissolution rate of tablets achieved an ideal state by using lactose as filler and 8% sodium carboxymethyl starch as a disintegrating agent. Compared with commercial tablets, the peak time of the self-made tablets advanced, and the peak concentration increased. The relative bioavailability was 149.95%. CONCLUSION This preparation of tablets can significantly improve the dissolution rate of FNB and improve the oral bioavailability.