Retrospective Analysis of the Adverse Drug Reaction Induced by Theophylline Drugs

OBJECTIVE To explore the features and contributing factors of adverse drug reaction(ADR) induced by theophylline drugs and provide rational use of drugs in clinic. METHODS A retrospective analysis was conducted on 132 cases of ADR publicly reported during the year from 1978 to 2013 via the use of CNKI, VIP and Wanfang Information System. RESULTS Of all the 132 cases, there were 78 male patients, accounting for 60%; 52 female patients, accounting for 40%. The ADR induced by aminophylline reach up to 107 cases, making up 81.06%, and clinic ADRs mainly observed on nervous system damage, digestive system damage, and the cardiovascular system. CONCLUSION Clinical doctors and pharmacists should understand the pattern and characteristics of ADR induced by theophylline drugs, and strengthen monitoring of its use in order to reduce occurrence of ADRs and provide reference for the prevention and therapy of ADR caused by theophylline drugs.