Determination of 10 Kinds of Residual Organic Solvents in Health Food Solid Preparations by GC and Its Confirmation by GC-MS

OBJECTIVE To establish a method for analysis of methanol, ethanol, acetone, isopropanol, n-hexane, ethyl acetate, benzene, 1,2-dichloroethane, n-butanol, and divinylbenzene in health food. METHODS A GC method with FID detector and DB-624 capillary column, and a GC-MS method with DB-624MS capillary column and EI ion-source had been established. RESULTS The calibration curves for the residual organic solvents were linear with r>0.99. The assay recoveries ranged in 85.2%-108.6% and the RSD was 1.0%-3.1%. CONCLUSION The detection limits of the method were lower than the residual organic solvents limits of Ch.P 2010 Ⅱ Appendix Ⅷ P. The method established can be used to detect 10 kinds of residual organic solvents in health food solid preparations.