Optimization Preparing Procedures of Gastric Floating Granules Loaded with Matrine

OBJECTIVE To prepare the gastric floating granules loaded matrine and to evaluate its properties. METHODS Using HPMC and octadecyl alcohol OA as major matrix, the optimal formulation of gastric floating granules loaded matrine was selected by L₉(3⁴) orthogonal design. Also, the two main properties of cumulative release and floating ability were comprehensively considered. RESULTS The optimum preparing procedures for this granules were followed as 2∶3 HPMC, 7% OA, 4% coating EC contained 0.8% PEG-4000, and coating weight gain approaching 1∶6. The granules presented satisfactory sustained release characteristics within 12 h in vitro, and occupied a significant floating characteristic, the release behavior followed with first-order kinetics. CONCLUSION The granules showed sustained release effect and floating ability. This product could be used as a new therapeutic dosage form for stomach tumor.