Effects of Moldavica Total Flavone on Interleukin-6, 13, 17 and Tumor Necrosis Factor-α Levels in Asthma Rats

OBJECTIVE To investigate the effects of moldavica total flavone on interleukin-6, 13, 17 and tumor necrosis factor-α levels in ovalbumin-induced asthmatic rats. METHODS Rats asthma model was established by ovalbumin challenge methods. After therapy by moldavica total flavone, TNF-α, IL-6, IL-13 and IL-17 in BALF were detected respectively by ELISA. RESULTS The levels of TNF-α, IL-6, IL-13 and IL-17 in BALF were markedly decreased(P<0.05 or P<0.01) after administration of 180 and 360 mg·kg^-1·d^-1 moldavica total flavone in ovalbumin-induced asthmatic rats. CONCLUSION Moldavica total flavone can inhibit the release of inflammatory cytokines of TNF-α, IL-6, IL-13 and IL-17 on asthma.