Progress in Synthesis of Topiramate

OBJECTIVE To introduce the background and current synthesis progress of topiramate. METHODS To review both domestic and international published reports regarding the synthesis of topiramate. RESULTS Made a list of synthesis methods of a key intermediate and four synthesis methods of topiramate including esterification, ammonolysis, catalytic hydrogenation and hydrolyzation and analyzing characteristics of synthesis methods. CONCLUSION The method of ammonolysis provides us a main research direction for efficient synthesis topiramate.