Chemical Structural Confirmation of Mezlocillin Sodium

OBJECTIVE To establish a method for the determination of the chemical structure of mezlocillin sodium. METHODS Thermal analysis(TA), elemental analysis(EA), ultraviolet absorption spectrum(UV), infrared Fourier transform spectroscopy(FT-IR), nuclear magnetic resonance(NMR) and mass spectrometry(MS) were adopted to analyze the chemical structure of mezlocillin sodium. RESULTS The chemical structure of mezlocillin sodium was (2S,5R,6R)-3,3-dimethyl-6- (R)-2-(3-methylsulfonyl-2-oxo-imidazolidin-1-yl)carbonylamino-2-phenyl-acetyl amino-7-oxo-4-thia-1-azabicyclo3.2.0 heptane -2-carboxylic acid sodium salt. CONCLUSION The result of the method is accurate, general and can provide a comprehensive reference for production and identification of mezlocillin sodium.