Terahertz Time-domain Spectroscopy of Lamivudine

OBJECTIVE The refractive index and absorption coefficient of lamivudine were measured by the THz-TDS system. The spectral response and the dispersive relationship of refractive index in the range were obtained which can be used in the qualitative analysis. METHODS The refractive index and absorption coefficient of lamivudine were measured by using the THz-TDS system. At the same time, Gaussian View software and B3LYP algorithm of density functional theory were applied to simulate the structure and vibration frequencies of lamivudine in THz spectral range. According to the results of simulation, the origin of experimental absorption peaks were interpreted with the help of Gaussian View. RESULTS The theoretical calculation result and experiment data tallied well. This showed that the accuracy of using THz spectrum to detect Lamivudine. CONCLUSION The THz-TDS system can be used in the qualitative analysis of lamivudine. The research results show that it is feasible to apply terahertz time-domain spectroscopy into the qualitative analysis of other drugs.