Analysis of Drug Resistance of ESBLs-product Klebsiella Pneumoniae and Escherichia Coli

OBJECTIVE To investigate the trend of antibiotic resistance of extended-spectrum β-lactamases(ESBLs) producing in our hospital, and to provide a guidance for clinical rational use of antibiotics. METHODS Klebsiella pneumoniae and Escherichia coli strains were collected, which were isolated from patients in clinical in 2006-2011. Bacterial susceptibility testing were detected by Vitek-32 automatic identification system. The results were evaluated based on Clinical and Laboratory Standards Institude(CLSI). RESULTS All of 1 563 strains of K. pneumoniae were considered ESBLs, the positive rate was 57.80%. All of 2 506 strains Escherichia coli considered ESBLs, the positive rate was 30.55%. Imipenem should be considered to be a preferred antibiotic when used on ESBLs producing K. pneumoniae and Escherichia coli infected cases. CONCLUSION ESBLs K. pneumoniae and Escherichia coli have the multidrug-resistant phenomenon. Surveillance should be intensified, so as to avoid the increasing, diffusive and popular of ESBLs-producing bacteria.