Determination of Fumaric Acid in Pharmaceutical Intermediate by Ion Chromatography

OBJECTIVE To develop an analytical method for the determination of fumaric acid in pharmaceutical intermediate product by ion chromatography. METHODS The determination of fumaric acid was achieved on a separation column IonPac AS11-HC with KOH as eluent, and the detection was performed by a conductivity detection mode. RESULTS The linear calibration was obtained over the range of 0.10-100.0 mg·L^-1 with a correlation coefficient of 0.999 9. The relative standard deviations(RSD) of retention time, peak area and peak height were 1ess than 1.05%(n=7). The detection limit of method was 0.014 mg·L^-1. The recoveries of added standard were 98.8%-100.6%. CONCLUSION The method is simple, fast and accurate for the determination of fumaric acid in the sample pharmaceutical intermediate.