The Study of Effection and Mechanism of Tangkening Granule on Rats Blood Glucose and Blood Fat

OBJECTIVE To investigate the effection and mechanism of Tangkening granule on rats blood glucose and blood fat． METHODS Rat diabetes models were made by injecting Steptozotocin（10 mg·kg-1）in intravenous followed by feeding high-lipid and high-sugar diat．Then administer the rats by Tangkening granule，and observed the change of weight and detected the contents of blood glucose，carbohydrate tolerance，hepatic glycogen，Insulin and insulin-like growth factor，tumor necrosis factor，HDL-C，LDL-C and so on． RESULTS Comparating with controlling group，Tangkening granule in evrery gloup can low the blood glucose obviously on experimental diabetic rats （P<0.05），can raise hepatic glycogen，HDL-C，Insulin and insulin-like growth factor and can degrade tumor necrosis factor，LDL-C． CONCLUSION The experiment results indicate that Tangkening granule can low the blood glucose and blood fat obviously，improve carbohydrate tolerance．The mechanism of controlling blood glucose and blood fat maybe related to raise hepatic glycogen and Insulin，improve Insulin Sensitivity and the ability of antioxidation，reduce the activity of MDA in the rats．