CHAI Yu-zhu, XU Jun, YAN Xiang-ping, DU Yun, WANG Pu-hai, LENG Zong-kang. Synthesis of class Ⅲ antiarrhythmic agent DofetilideJ. Chinese Journal of Modern Applied Pharmacy, 2004, (5): 377-378.
Citation:
CHAI Yu-zhu, XU Jun, YAN Xiang-ping, DU Yun, WANG Pu-hai, LENG Zong-kang. Synthesis of class Ⅲ antiarrhythmic agent DofetilideJ. Chinese Journal of Modern Applied Pharmacy, 2004, (5): 377-378.
CHAI Yu-zhu, XU Jun, YAN Xiang-ping, DU Yun, WANG Pu-hai, LENG Zong-kang. Synthesis of class Ⅲ antiarrhythmic agent DofetilideJ. Chinese Journal of Modern Applied Pharmacy, 2004, (5): 377-378.
Citation:
CHAI Yu-zhu, XU Jun, YAN Xiang-ping, DU Yun, WANG Pu-hai, LENG Zong-kang. Synthesis of class Ⅲ antiarrhythmic agent DofetilideJ. Chinese Journal of Modern Applied Pharmacy, 2004, (5): 377-378.
Synthesis of class Ⅲ antiarrhythmic agent Dofetilide
OBJECTIVE To synthesize dofetilide and optimize the process. METHOD Dofetilide was synthesized by steps of reaction (substitution ,reduction, methylsulfonylation and methylammoniation, etc) from p-nitrophenol and p-amino phenethyl alcohol. RESULTS Chem
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