Quality Control and Dissolution Rate of Minocycline Hydrochloride Film

OBJECTIVE To determine the dissolution rate of minocycline hydrochloride film and study its quality. METHODS The dissolution test of minocycline hydrochloride film was conducted according to Ch.P(2010), the main content of them was determined by HPLC, the accumulative dissolution rate was computed, the dissolution parameters of Td and m were caculated by Weibull formula, then correlation test was carried out. RESULTS There were no significant differences interclass parameters and interblock parameters of five batches of simples(P>0.05). CONCLUSION The formulation of minocycline hydrochloride film is reasonable, the process of preparation is feasible and the quality is dependable.