ZHANG Wanggang, WANG Qiao, CHEN Guoshen, JIN Yi. Study on Procaterol Hydrochloride Sublingual Dropping Pill and Stability[J]. Chinese Journal of Modern Applied Pharmacy, 2011, 28(6): 542-545.
    Citation: ZHANG Wanggang, WANG Qiao, CHEN Guoshen, JIN Yi. Study on Procaterol Hydrochloride Sublingual Dropping Pill and Stability[J]. Chinese Journal of Modern Applied Pharmacy, 2011, 28(6): 542-545.

    Study on Procaterol Hydrochloride Sublingual Dropping Pill and Stability

    • OBJECTIVE To optimize the formulation technology of procaterol hydrochloride sublingual dropping pill and study the stablity. METHODS The optimal preparation technology was selected by the orthogonal experiment, using the forming effect, weight variation and dissolution time as evalution indexs. And the stability of three batches of samples simulated market packaging was also studied according to Ch.P(2005). RESULTS The optimal condition of procaterol hydrochloride sublingual dropping pill was procaterol hydrochloride 0.007 g, PEG4000 5 g, PEG6000 15 g and poloxamer F68 15 g, the coolant temperature was 8 ℃, the dropping temperature was 65 ℃, and the distance between dropping head and coolant surface was 5 cm. The characteristics, content, related substances, dissolution time of procaterol hydrochloride sublingual dropping pill were no significant changes through the six months accelerated test and 12 months long-term test. CONCLUSION The optimized preparation technology of procaterol hydrochloride sublingual dropping pill is easy, and the stability is good.
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