Application of Hot Melt Granulation in Oral Solid Dosage Forms

In recent times, various methods of hot melt granulation have been adopted in the preparation of oral solid dosage forms, such as granules, tablets and capsules. This paper presents a review of these methods’ features, equipments, binders, applications, tendencies, problems and solutions of industrial production. Special emphasis is put on binders with low melt point and different solubility, which play crucial roles in hot melt granulation.