Establishment and Application of Evaluation Criteria for Clinical Rational Drug Use of Oliceridine Based on AHM-TOPSIS Method

OBJECTIVE To evaluate the clinical rationality of using oliceridine based on the attribute hierarchy model(AHM) and the technique for order preference by similarity to an ideal solution(TOPSIS) method, providing reference for the rational use and scientific management of oliceridine in clinical practice.

METHODS Based on the instructions of oliceridine fumarate injection, combined with guidelines, consensus and relevant literature, the criteria of rational drug use evaluation for oliceridine was established. The relative weight of each evaluation index was established by the AHM method. The TOPSIS method was used to retrospectively evaluate 260 prescriptions of oliceridine from October 2024 to September 2025 in the Second Affiliated Hospital of Soochow University. The evaluation results were divided into three levels including reasonable, basic reasonable and unreasonable application based on the compliance index(C_i).

RESULTS The evaluation indexes for evaluating the rational use of oliceridine, ranked by relative weight, placed the top three as indications(weight 0.1635), dosage and administration(weight 0.1472), and route of administration(weight 0.1361). Among 260 prescriptions evaluated using the oliceridine rational use criteria, the indicators with the highest to lowest rates of irrational use were economy, concomitant medication, dosage and administration, efficacy evaluation, special populations, adverse drug reaction management, and contraindications. According to the weighted TOPSIS method, 55 prescriptions(21.15%) were classified as reasonable(C_i≥80%), 11 prescriptions(4.23%) as basic reasonable(60%≤C_i<80%), and 194 prescriptions(74.62%) as unreasonable (C_i<60%).

CONCLUSION The rationality evaluation criteria of oliceridine’s clinical application are established by AHM-TOPSIS method, and the evaluation results obtained by this method are quantifiable, scientific and reliable. The unreasonable use of oliceridine is common in the Second Affiliated Hospital of Soochow University, and the management should be strengthened in clinical application.