Research Progress of Prolonged Low-dose Infusion for Gemcitabine

Gemcitabine(GEM) is a kind of anti-pyrimidine nucleotide metabolism drug. At present, the standard dose of GEM is 1 000-1 250 mg·m^-2, intravenous infusion for 30 min. However, pharmacological studies have shown that GEM with prolonged infusion can improve the accumulation rate of GEM triphosphate(dFdCTP), suggesting that prolonged infusion of GEM is superior to 30 min infusion in pharmacokinetics. This paper review the related research of GEM with prolonged low-dose infusion in order to provide the basis for it's clinical medication.