Study on Preparation of Levetiracetam Sodium Extended-release Tablet and It's Pharmacokinetics in Beagle Dogs

OBJECTIVE To prepare the Levetiracetam extended-release tablet and investigate its pharmacokinetics in Beagle dogs and in vitro release. METHODS Prearation of Levetiracetam extended-release tablet according to optimized prescription, choosed sell products(Keppra-XR) as reference products, evaluation of in vitro release behavior similarity by the similar factor(f₂). The pharmacokinetic parameters were compared between the self-made extended-release tablet and the sell tablet. RESULTS The self-made extended-release tablet was similar to the reference products in vitro release, T_max of reference products and self-made extended-release tablet were (1.75±0.50) and (5.50±1.00) h, C_max were (30.33±2.00) and (17.29±3.56) mg·L^-1, AUC_0-t were (186.88±8.83) and (202.50±34.20) mg·L^-1·h. CONCLUSION The self-made Levetiracetam extended-release tablet exhibits the sustained release characteristics in vitro.