Characterization Study of Polymorphism of Doxazosin Mesylate

OBJECTIVE To study the characterization of doxazosin mesylate forms and provide polymorphic research material.METHODS Characterization spectrum of form A and form H of doxazosin mesylate were detected by X-ray powder diffraction(XRPD), differential scanning calorimeter(DSC), thermo-gravimetric analysis(TG), infrared radiation(IR), Raman spectra analysis and dissolution test.RESULTS Characterization figures of form A and form H were obtained.CONCLUSION Form A and form H show difference in XRPD, DSC and TG patterns, form H has better performance in dissolution test.