Abstract: OBJECTIVE To investigate the changes of anti-anxiety and anti-depression prescriptions in a large general hospital over the 5 years and to find the trend of drug therapy. METHODS reviewed the prescriptions of anxiety and depression disorder patients in outpatient, respectively in 2010 and 2015, and analyzed the proportion of medication. RESULTS In 2015, the most medication for anxiety and depression disorder were SSRI, SGA, BDZ, SNRI. The most of proportion were SSRI and SNRI in monotherapy, and SSRI, SNRI and SGA in combined treatment. The large changes between 2015 and 2010 were that proportions of β-blockers and TCAs were dropping dramatically and the combined treatment with 3 drugs was replaced by 2 drugs in the majority medication. CONCLUSION Medication for anxiety and depression disorder in the general hospital tends to choice the higher efficacy and mildly side-effect drugs and combined treatment.