Abstract: OBJECTIVE To conduct a survey on investigating the common sense of drug usage and the demand of pharmacy service among patients with severe mental illness, provide a much more efficiency community pharmacy care in Wenzhou. METHODS A questionnaire survey was conducted in 12 counties of Wenzhou, and the data were statistically analyzed. RESULTS 92.27% severe mental illness patients had a high school or below educational background. more than half patients had problems in usage and dosage, medication time, misused, didn’t know how to deal with adverse reactions, and so on. 78.97% patients will sought help from doctors when encounter problems. 62.3% patients took combined medication strategy, and more than half take atypical antipsychotics drugs. Less than half patients were in full compliance with medicine taking. Adverse reactions, such as somnolence, dry mouth, hypomnesis, constipation, gain weight and so on, occur in a vast majority patient. CONCLUSION There is a great demand of community pharmacy service for severe mental illness patients in Wenzhou. It can be carried out at three aspects as followed: establish a perfect pharmacy service team, give efficiency publicity and advertising, make service much more convenient and flexibility in multiple channel.