Abstract: OBJECTIVE To evaluate effectiveness and safety of omeprazole treatment of uremia complicated with upper gastrointestinal hemorrhage. METHODS Such databases as Pubmed, EMbase, the Cochrane Library, EBSCO, CNKI, Wanfang Data, VIP, CBM were searched to collect RCTs. The bias risk assessment and meta analysis were conducted by RevMan 5.3 and STATA 11.0. RESULTS Compared with the control group, the total efficiency of omeprazole in the treatment of uremia complicated with upper gastrointestinal hemorrhage had significant difference(P<0.000 01). Compared with H₂ receptor antagonist group or blank control group, the total effective rate of hemostasis had significant difference (P<0.000 01 or P<0.000 1). The effective end judgment was different, results showed that 72 h or 96 h for efficacy endpoint both had statistical difference(P<0.000 01). The safety of omeprazole group and control group showed no significant difference between the occurrence of adverse drug reactions. CONCLUSION Omeprazole in the treatment of uremia complicated with upper gastrointestinal hemorrhage is safe and effective. But given in the study has certain limitations, and therefore a large sample of high-quality clinical trials still need to be verified.