Abstract: OBJECTIVE To overview the risk of decreasing the blood drug concentration of valproate caused by the combination carbapenems and valproate after brain tumor operation, and then draw propose solutions. METHODS It analyzed its mechanism and proposes potential solutions by analyzing drug instructions and literatures concerned. RESULTS According to the drug instructions and the existing literatures, carbapenems could decrease the blood drug concentration of valproate. Therefore, more efforts should be made on the research of strengthening the monitor of blood drug concentration of valproate and on dose security would provide practical support for safe clinical application. CONCLUSION Carbapenems can decrease the blood drug concentration of valproate in brain tumor operation treatment combinding carbapenems with valproate. Therefore, how to apply the combination of the drug safely is supposed to be actualized.