抗癌灵活性部位对不同肿瘤细胞的抑制作用

叶强; 睢凤英; 杨鑫骥; 王嘉

抗癌灵活性部位对不同肿瘤细胞的抑制作用

Anti-tumor Effect of Kang Ai Ling’s Active Site on Different Cancer Cells

摘要

摘要: 目的研究抗癌灵正丁醇提取部位(以下简称KAL)对多种肿瘤细胞的抑制率以及时效和量效关系。方法采用MTT法考察KAL对肿瘤细胞B-16、SGC-7901、Colo320、PC-3、HL60的抑制率以及IC₅₀；通过观察KAL对肿瘤细胞SGC-7901和PC-3生长的影响，考察其时效和量效关系。结果 KAL对肿瘤细胞B-16、SGC-7901、Colo320、PC-3、HL60的IC₅₀分别为：(21.05±4.31)，(13.43±4.78)，(15.17±3.82)，(26.39±5.76)，(25.78±4.40)μg·mL^-1，且在抑制肿瘤细胞过程中呈现明显的时效关系和量效关系。结论 KAL对肿瘤细胞B-16、SGC-7901、Colo320、PC-3、HL60具有显著抑制作用。

Abstract: OBJECTIVE To observe the growth inhibitory effect of tumor cells by Kang Ai Ling’s 1-butanol exrtract(KAL). METHODS The anti-proliferative activities of 1-butanol extract of KAL against B-16, SGC-7901, Colo320, PC-3 and HL60 cells were evaluated by MTT colorimetric assay in vitro, then the result showed by inhibitory rate and IC₅₀. Investigation on KAL’s dose-effect dependent manner and time-effect dependent manner through growth inhibitory curve on SGC-7901 and PC-3. RESULTS The IC₅₀ of KAL on B-16, SGC-7901, Colo320, PC-3 and HL60 were (21.05±4.31), (13.43±4.78), (15.17±3.82), (26.39±5.76), (25.78±4.40)μg·mL^-1, respectively. The anti-tumor effect of KAL has obvious time-effect and dose-effect dependence. CONCLUSION KAL has significant growth inhibitory effect on B-16, SGC-7901, Colo320, PC-3 and HL60 cells.

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