Abstract: OBJECTIVE To establish a method for the quality evaluation of Daidai Flavones dropping pills. METHODS TLC was applied to the identification of Daidai Flavones dropping pills and to check heavy metal and arsenic salts in Daidai Flavones dropping pills. In addition, the contents of naringin and neohesperidin in Daidai Flavones dropping pills was determined by HPLC. RESULTS The qualitative identification with TLC was specific, and negative control had no interference. The contents of heavy metals and arsenic salts were less than ten over one million of Daidai Flavones dropping pills. Neohesperidin had a good linearity in the range of 4.088-16.352 μg·mL^-1, naringin had a good linearity in the range of 4.084?16.336 μg·mL^-11. The average contents of neohesperidin in three batches of daidai flavones dropping pills were 75.32, 74.82, 73.76 mg·g^-1, respectively; and naringin were 63.05, 63.21, 62.07 mg·g^-1, respectively. CONCLUSION The established method is stability and simple, and can be used to control the quality of Daidai Flavones dropping pills effectively.