Abstract: OBJECTIVE To explore the risk influence factors of hospital preparations, evaluate the risk and put forward the methods to prevent and control the risk of hospital preparations. METHODS Assume that was likely to affect the hospital preparations hypothesized risk factors, design questionnaire, use SPSS 17.0 to evaluate the reliability and validity of the questionnaire; and use EXCEL 2003 to add up results of the questionnaire. RESULTS Hospital preparations risk factors included 4 aspects: quality control of preparations, related national policy, basic theory and use procedure. Among these, the quality control of preparation and related national policy were the major influence factors. CONCLUSION From two aspects of preparations itself and human factors, the risk of hospital preparations will reduce.