Abstract: OBJECTIVE To observe the effect of dehumidifying detoxification decoction combined with Recombinant Human Interferon α-2b Vaginal Effervescent capsules in the treatment of cervical high risk HPV infection. METHODS Cervical high risk HPV infection patients were randomly divided into three groups: 50 cases in follow-up group, non drug intervention; 65 cases in the western medicine group, Recombinant Human Interferon α-2b Vaginal Effervescent capsules treatment for 3 courses; 65 cases in Chinese western medicine group, treated with Recombinant Human Interferon α-2b Vaginal Effervescent capsules and oral self-made dehumidifying detoxification decoction for 3 courses. Observation of the effects of 3 groups. RESULTS Efficacy of the western medicine group and the Chinese western medicine group were significantly higher than follow-up group in cervical disease, TCM syndromes, HPV negative conversion, the difference was statistically significant(P<0.01). The comparison between the western medicine group and the Chinese western medicine group, there was no significant difference in the total efficiency of the treatment of cervical lesions, but the significant efficiency in Chinese western medicine group was 60.00%, higher than that of 41.54% in Western medicine group, the difference was statistically significant(P<0.05). There was no significant difference in the total efficiency of the treatment of TCM syndromes, but the significant efficiency in Chinese western medicine group was 69.23%, higher than that of 46.15 % in western medicine group, the difference was statistically significant(P<0.01). The total efficiency in HPV negative conversion was 67.69% in western medicine group and 83.08% in Chinese western medicine group, the difference was statistically significant(P<0.05). CONCLUSION Drug intervention of cervical high risk HPV infection has a positive meaning. It has the advantage in effect of HPV scavenging and improve the symptoms, physical signs in the Chinese medicine combined with western medicine.