Abstract: OBJECTIVE To observe the effect of total parenteral nutrition(TPN) and parenteral nutrition(PN) combined with enteral nutritional(EN) supports on postoperative nutrition and the incidence of complications of patients with radical gastrectomy. METHODS The 58 cases of patients with radical gastrectomy divided into TPN group and PN+EN group(n=29). Each group were given enteral or parenteral combined with enteral nutrational support began at the first day after operation. Body weight, ALB, Hb, WBC between preoperation and postoperattion, the anal exsufflation time, infectious complication rate and duration of hospital stay were measured. RESULTS There was no significant difference between the two groups on postoperative body weight, ALB, Hb, WBC and duration of hospital stay. The anal exsuffation time was significantly longer and infectious complication rate was higher in TPN group than PN+EN group(P<0.05). CONCLUSION The two nutritional support methods can both improve the nutritional status. EN can reduce the incidence of infection of patients and improve intestinal recovery in patients with radical gastrectomy.