Abstract: OBJECTIVE To compare the preemptive analgesic effects of flurbiprofen and parecoxib in vitrectomy. METHODS Seventy-five patients undergoing monitored anaesthesia care were randomly divided into 3 groups: control group, flurbiprofen group and parecoxib group. The visual analogue scale (VAS) and postoperative nausea and vomiting (PONV) were recorded within 24 h. RESULTS Compared with control group, VAS scores were significantly lower in flurbiprofen group and parecoxib group at 1, 3, 6 h(P<0.05). There were no significant differences among three groups in the incidence of PONV. CONCLUSION Flurbiprofen and parecoxib can offer more effective and safer analgesia for perioperative pain relief than saline in vitrectomy.