Abstract: OBJECTIVE To compare the curative effects and pharmaceconomical efficacy of 3 drugs in the treatment of mild or moderate essential hypertension. METHODS A total of 150 cases of hypertension patients were randomly divided into 3 groups, group A (amlodipine besylate, 2.5 mg·d^-1), group B (irbesartan, 150 mg·d^-1), group C (felodipine sustained release, 5 mg·d^-1). During the treatment, patients’ compliance with questions and follow-up survey were investigate. The curative effects in each group were observed, and the cost-effectiveness ratios were analyzed after 8-week treatment. RESULTS The total effective rates of the 3 groups(A, B, and C) were 78.0%, 80.0% and 84.0%, respectively. The cost-effectiveness ratios were 59.36, 147.84 and 222.32 yuan, respectively. The best compliance was observed in group A. CONCLUSION Antihypertention therapy should be economic, reasonable, safe and effective. Amlodipine besylate treatment is more reasonable.