Abstract: OBJECTIVE To investigate the effect of crude polysaccharides from Arnebia euchroma (Royle) Johnst(ARPS) anti-tumor of mice bearing uterine cervical carcinoma (U14) in vivo. METHODS The effect of ARPS on the inhibition rate of solid tumor, thymus index, spleen index and the life span of ascites tumor were conducted with the experiment model in vivo of animal tumor. RESULTS ARPS had obvious anti-tumor effects to U14-mice (P<0.05), could prolong U14-mice life, and medium dose group increased effect on spleen index (P<0.05), high and medium dose groups decreased effects on thymus index (P<0.05). CONCLUSION The result indicated that ARPS could inhibited the development of U14 cervical cancer in mice.