Abstract: OBJECTIVE To compare the therapeutic effect of Pule’an tablet and Prostat tablet on chronic prostatitis in a randomized, opening, parallel controlled, multi-center clinical study. METHODS A total of 174 patients with diagnosed chronic prostatitis were randomly separated into two groups: 133 patients in therapy group were dosed 4 tablets of Pule’an tablet by 3 times a day, while 41 patients in control group were dosed 1 tablet of Prostat tablet by twice a day. Both groups were treated for 8 weeks. Symptoms, prostate conditions and changes of prostatic fluid were observed in the study. RESULTS The total effective rate in the therapy group was 77.44%, contrasted with 80.49% in the control group. There was no significant difference between the two groups (P>0.05). CONCLUSION Pule’an tablet is an ideal plant medicine recently for chronic prostatitis.