大叶钩藤根的化学成分研究

Chemical Constituents of the Root of Uncaria macrophylla

摘要: 目的研究大叶钩藤(Uncaria macrophylla Wall.)根的化学成分。方法用甲醇提取及柱色谱等方法进行分离，波谱法鉴定结构。结果从大叶钩藤根部位中分离并鉴定了6个化合物，其结构分别为钩藤碱(1)、异钩藤碱(2)、乌苏酸(3)、b-谷甾醇(4)、taraxerol(5)、myricadoil(6)。结论首次报道大叶钩藤根的化学成分；实验结果可为大叶钩藤的进一步研究开发提供科学依据。

Abstract: OBJECTIVE To study the chemical constituents of the root of Uncaria macrophylla Wall.. METHODS The plant was extracted by MeOH, then separated and repeatedly purified by methods of chromatography. Their structures were elucidated by IR, MS and NMR. RESULTS Six compounds were obtained and identified as rhynchophylline(1), isorhynchophylline(2), ursolic acid(3), b-sitosterol(4), taraxerol(5), myricadoil(6). CONCLUSION Chemical constituents of the root of Uncaria macrophylla were reported for the first time. These results would be benefit to the further investigation of this plant.